منابع مشابه
Effect of alloxan-diabetes on gluconeogenesis and ureogenesis in isolated rabbit liver cells.
1. Neither alloxan-diabetes nor starvation affected the rate of glucose production in hepatocytes incubated with lactate, pyruvate, propionate or fructose as substrates. In contrast, glucose synthesis with either alanine or glutamine was increased nearly 3- and 12-fold respectively, in comparison with that in fed rabbits. 2. The addition of amino-oxyacetate resulted in about a 50% decrease in g...
متن کاملControl of Gluconeogenesis in Rat Liver Cells
Control of gluconeogenesis from lactate was studied by titrating rat liver cells with lactate and pyruvate in a ratio of 1 O : l in a perifusion system. At different steady states of glucose formation, the concentration of key gluconeogenic intermediates was measured and plotted against gluconeogenic flux (Jglucoee). Complete saturation was observed only in the plot relating JglUcto the extrace...
متن کاملglycolysis/gluconeogenesis in regenerating rat liver
Levels of mRNA for glucokinase, L-pyruvate kinase, fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase were analysed during liver regeneration. Levels of mRNA for glycolytic enzymes (glucokinase and L-pyruvate kinase) decreased rapidly after partial hepatectomy. Glucokinase mRNA increased at 16-24 h, returning to normal values after this time. L-pyruvate kinase mRNA recovered cont...
متن کاملGluconeogenesis in Neonatal Piglet Liver 1
The gluconeogenic capacity of livers from day old and 5-day-old piglets has been studied. The data show infused piglets and perfused livers convert lactate to glucose. Studies with isolated liver mitochondria show a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolypyruvate. Factors that affect accumulation of ma...
متن کاملGluconeogenesis from amino acids in neonatal rat liver.
1. The utilization of amino acids for gluconeogenesis by rat liver develops in postnatal life, reaching maximum activity at the fifth day. 2. The activity of aspartate transaminase shows a similar trend in postnatal development and the increased activity appears to be due to the soluble enzyme. 3. The activity of alanine transaminase is low in foetal and postnatal rat liver and increases in act...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44333-0